Sm qnr , a New Chromosome-Carried Quinolone Resistance Gene in Stenotrophomonas maltophilia

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منابع مشابه

Novel variants of the Smqnr family of quinolone resistance genes in clinical isolates of Stenotrophomonas maltophilia.

BACKGROUND Recent analysis of Stenotrophomonas maltophilia has identified a novel family of resistance genes (Smqnr) encoding pentapeptide repeat proteins, which confer low-level resistance to quinolones. This study describes further novel variants present in clinical isolates of S. maltophilia and investigates their effect on resistance to a number of quinolones in an Escherichia coli host. ...

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Multiple antibiotic resistance in Stenotrophomonas maltophilia.

A cryptic multidrug resistance (MDR) system in Stenotrophomonas maltophilia, the expression of which is selectable by tetracycline, is described. Tetracycline resistance was the consequence of active efflux of the antibiotic, and it was associated with resistance to quinolones and chloramphenicol, but not to aminoglycosides or beta-lactam antibiotics. MDR is linked to the expression of an outer...

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Antimicrobial Resistance Pattern of Stenotrophomonas maltophilia Isolates from a Tertiary Care Setting in Rawalpindi, Pakistan

Introduction: Stenotrophomonas maltophilia is intrinsically resistant to many antimicrobials. Like Pseudomonas spp., this bacterium has a remarkable ability to cause infections, particularly in the respiratory and urinary tracts. This study aims to determine the antimicrobial resistance pattern of S. maltophilia isolates collected from a tertiary care setting and frequency of multi, extensively...

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Whole-genome sequencing identifies emergence of a quinolone resistance mutation in a case of Stenotrophomonas maltophilia bacteremia.

Whole-genome sequences for Stenotrophomonas maltophilia serial isolates from a bacteremic patient before and after development of levofloxacin resistance were assembled de novo and differed by one single-nucleotide variant in smeT, a repressor for multidrug efflux operon smeDEF. Along with sequenced isolates from five contemporaneous cases, they displayed considerable diversity compared against...

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Stenotrophomonas maltophilia in Salad

To the Editor: Stenotrophomonas maltophilia has emerged as an important nosocomial pathogen, especially in debilitated and immunocompro-mised persons (1). However, comparatively little is known of the epidemiology of this bacterium, and sources and routes of transmission of S. mal-tophilia are not well understood. The bacterium is widely distributed in the environment, including in plant rhi-zo...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 2008

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.00026-08